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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NIPBL
All Species:
22.73
Human Site:
S2221
Identified Species:
55.56
UniProt:
Q6KC79
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6KC79
NP_056199.2
2804
316051
S2221
N
L
Y
N
N
I
L
S
D
K
N
S
S
V
N
Chimpanzee
Pan troglodytes
XP_001146002
2804
316033
S2221
N
L
Y
N
N
I
L
S
D
K
N
S
S
V
N
Rhesus Macaque
Macaca mulatta
XP_001096462
2804
316103
S2221
N
L
Y
N
N
I
L
S
D
K
N
S
S
V
N
Dog
Lupus familis
XP_546344
2804
316124
S2221
N
L
Y
N
N
I
L
S
D
K
N
S
S
V
N
Cat
Felis silvestris
Mouse
Mus musculus
Q6KCD5
2798
315432
S2215
N
L
Y
N
S
I
L
S
D
K
N
S
S
V
N
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509151
2821
317768
S2238
N
L
Y
N
S
I
L
S
D
K
N
S
S
V
N
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001154919
2856
323576
A2237
N
L
Y
N
T
L
L
A
D
R
K
T
S
V
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q7PLI2
2077
236710
A1524
F
D
F
K
S
P
I
A
L
G
E
T
N
D
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q95XZ5
2203
252800
K1650
K
F
K
R
G
A
T
K
T
I
D
V
F
S
T
Sea Urchin
Strong. purpuratus
XP_793995
2228
251283
L1674
I
S
V
K
Q
L
C
L
V
V
R
N
L
H
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99.2
98
N.A.
96.6
N.A.
N.A.
91.8
N.A.
N.A.
68.6
N.A.
26.6
N.A.
25.1
37.9
Protein Similarity:
100
100
99.7
99.1
N.A.
98.7
N.A.
N.A.
95.8
N.A.
N.A.
80.8
N.A.
44.4
N.A.
43.4
54.6
P-Site Identity:
100
100
100
100
N.A.
93.3
N.A.
N.A.
93.3
N.A.
N.A.
60
N.A.
0
N.A.
0
0
P-Site Similarity:
100
100
100
100
N.A.
100
N.A.
N.A.
100
N.A.
N.A.
86.6
N.A.
40
N.A.
6.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
10
0
20
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% C
% Asp:
0
10
0
0
0
0
0
0
70
0
10
0
0
10
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% E
% Phe:
10
10
10
0
0
0
0
0
0
0
0
0
10
0
0
% F
% Gly:
0
0
0
0
10
0
0
0
0
10
0
0
0
0
10
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% H
% Ile:
10
0
0
0
0
60
10
0
0
10
0
0
0
0
0
% I
% Lys:
10
0
10
20
0
0
0
10
0
60
10
0
0
0
0
% K
% Leu:
0
70
0
0
0
20
70
10
10
0
0
0
10
0
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
70
0
0
70
40
0
0
0
0
0
60
10
10
0
70
% N
% Pro:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
10
0
0
0
0
0
10
10
0
0
0
0
% R
% Ser:
0
10
0
0
30
0
0
60
0
0
0
60
70
10
0
% S
% Thr:
0
0
0
0
10
0
10
0
10
0
0
20
0
0
10
% T
% Val:
0
0
10
0
0
0
0
0
10
10
0
10
0
70
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
70
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _